Programme overview

Morning
Midday
Afternoon
Evening
Wednesday 25 September 2019
Registration Opening Session 1 - KLK genetics and beyond (genetics, genomics, other ‘omics’ technologies) Coffee break Session 1 - KLK genetics and beyond (genetics, genomics, other ‘omics’ technologies)
Lunch
Session 2 - KLKs in malignant diseases (biomarkers and pathophysiology) Coffee break Session 2 - KLKs in malignant diseases (biomarkers and pathophysiology) Judith Clements - "The Yin & Yang of KLKs in cancer" Poster session
Welcome cocktail
Morning
Midday
Afternoon
Evening
Thursday 26 September 2019
Session 3 - KLKs in physiology and pathophysiology (physiologic systems and diseases) Coffee break Session 3 - KLKs in physiology and pathophysiology (physiologic systems and diseases)
Lunch and Poster session
Session 4 - KLKs in tissue and cell signaling Coffee break Session 5 - Therapeutic potential of KLKs (& Drug design)
Gala dinner
Morning
Midday
Afternoon
Evening
Friday 27 September 2019
Session 6 - Structural and functional aspects of Kallikreins, their substrates and inhibitors Coffee break Session 7 - KLKs in proteolytic (activation) networks
Lunch
HENNER GRAEFF Foundation & E.K. Frey - Werle Foundation session ISK2019 Young researchers awards Closing lecture - Eleftherios Diamandis - "Kallikrein memoirs and future predictions" Closing
 

 

Detailed programme (will be announced later) Print programme

Wednesday, 25 September 2019

10:00 - 10:30 Opening - Radislav Sedláček
10:30 - 11:00 Andreas Scorilas - "Identification of novel Kallikrein gene isoforms and their targeted non conding RNAs. A new area of novel tumor biomarkers"
11:00 - 11:15 Beatriz Pérez-González - "Epigenetic regulation of the Kallikrein family"
11:15 - 11:45 Coffee break
11:45 - 12:15 Joytsna Batra - "A functional PSA prostate cancer susceptibility genetic variant confers both reduced and aggressive cancer risk"
12:15 - 12:30 Hannu Koistinen - "KLK transcript levels in prostate cancer"
12:30 - 14:00 Lunch
14:00 - 14:30 George Yousef - "In silico navigation of Kallikrein gene expression in different malignancies and their potential clinical utility"
14:30 - 14:45 Adriana Krizova - "Distinct KLK3 expression can aid pathologists in differential diagnosis of benign structures vs. prostatic carcinoma"
14:45 - 15:00 Maria Brattsand - "KLK4 and Prostate Cancer"
15:00 - 15:15 Annie Ren - "Individualizing ovarian cancer treatment with KLKs as novel personalized biomarkers of therapeutic response and relapse"
15:15 - 15:45 Coffee break
15:45 - 16:00 Weiwei Gong - "Clinical relevance of kallikrein-related peptidase 5 and 7 mRNA expression levels in tumor tissue of advanced high-grade serous ovarian cancer patients (FIGO III/IV)"
16:00 - 16:15 Julia Dorn - "High levels of KLK7 protein expression are related to a favorable prognosis in triple-negative breast cancer patients"
16:15 - 16.45 Judith Clements - "The Yin & Yang of KLKs in cancer"
16:45 - 18.00 Poster session
18:00 - 20:00 Welcome cocktail

Thursday, 26 September 2019

09:15 - 09:45 Georgia Sotiropoulou - “Revealing unsuspected roles of KLKs in skin pathologies”
09:45 - 10:00 Evgeniya Petrova - "Spink5 conditional knock-out mice represent a viable model of Netherton syndrome allowing further understanding of skin and immune abnormalities"
10:00 - 10:30 Alain Hovnanian - "Epidermis-specific Kallikrein 14 overexpression in transgenic mice leads to major hair shaft defects, desmoglein 3 and 4 degradation and skin inflammation"
10:30 - 11:00 Coffee break
11:00 - 11:30 Yves Courty - "Differential roles of KLKs in influenza virus infection"
11:30 - 11:45 Woodys Lenga Ma Bonda - "Role of the kallikrein-related peptidase 5 in the bronchial epithelial remodeling associated with chronic obstructive pulmonary disease and lung cancer"
11:45 - 12:15 Tangsheng Yi - "KLK5 in airway inflammation and epithelial barrier dysregulation"
12:15 - 13:30 Lunch and Poster session
13:30 - 14:00 Morley Hollenberg - "Proteinase-mediated signalling in the inflammatory tissue microenvironment: KLKs, proteinase-activated receptors (PARs) and more"
14:00 - 14:15 Oliver Goldhardt - "Kallikrein-related peptidase 6 in cerebrospinal fluid of patients with alzheimer’s disease is associated with CSF-TAU, FDG and AMYLOID-PET"
14:15 - 14:30 Klaudia Brix - "Kallikreins and cysteine cathepsins act at opposite poles of thyroid epithelial cells"
14:30 - 14:45 Darian Williams - "the role of mechanosensitive KLK10 in endothelial biology and atherosclerosis"
14:45 - 15:00 Michael Jeltsch - "KLK3 activates VEGF-C and VEGF-D"
15:00 - 15:30 Coffee break
15:30 - 16:00 Jonathan Harris - "Design and recombinant production of a bispecific inhibitor of KLK5 and KLK7"
16:00 - 16:15 Caitlin Di Paolo - "Novel putative kallikrein-7 inhibiting compounds identified through a fluorescence-based enzyme kinetic screen of a targeted library"
16:15 - 16:45 Chahrazade El Amri - "Pharmacological modulators of kallikrein-related peptidases: conception, characterisation and therapeutical applications in inflammation and neurodegeneration"
19:00 - 22:00 Gala dinner

Friday, 27 September 2019

09:15 - 09:45 Peter Goettig -“The dynamic structure of KLK8 in activity and inhibition”
09:45 - 10:15 Hans Lilja - "Elucidating the effects of chymotrypsin-like and trypsin-like catalytic activity by prostate specific antigen and human kallikrein 2 on prostate tissue microenvironment, tumorigenesis and blood release"
10:15 - 10:30 Niv Papo - "Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries"
10:30 - 11:00 Coffee break
11:00 - 11:15 Thomasz Kantyka - "Processing of pro-MMPs by KLK14 - a new level of extracellular matrix proteolysis"
11:15 - 11:30 Katharina Käfinger - "KLK4-mediated cleavage of CXCR3-ligands as an immune evasion mechanism in ovarian cancer"
11:30 - 11:45 Leran Zhang - "Unlocking the KLK activome in drug-resistant cancer: imaging, biomarkers and target validation using novel activity probes"
11:45 - 13:00 Lunch
13:00 - 13:10 Viktor Magdolen - History of HENNER GRAEFF Foundation & E.K. Frey - Werle Foundation of the Henning L. Voight Family
13:10 - 13:20 Judith Clements - Laudation for the 2019 Joint Frey-Werle Foundation and Henner Graeff Foundation Promotion Prize Awardee
13:20 - 13:50 Daniela Loessner (Promotion Prize Awardee) - "Kallikrein-related peptidases are key elements in the tumour microenvironment"
13:50 - 14:10 Henner Graeff Foundation Young Investigator Award - Amiram Sananes - "Combinatorial Engineering of APPI Variant with Improved Proteolytic Resistance and KLK6 Selectivity for Cancer Imaging and Therapy"
14:10 - 14:30 E.K. Frey - Werle Foundation - Young Investigator Award - Srilakshmi Srinivasan - "Prostate cancer risk associated Single Nucleotide Polymorphism affects PSA glycosylation and its function"
14:30 - 14:45 ISK2019 Young researchers awards (Radislav Sedláček)
14:45 - 15:15 Closing lecture - Eleftherios Diamandis - "Kallikrein memoirs and future predictions"
15:15 - 15:20 Closing - Radislav Sedláček